Alzheimer's Disease (AD) is the most common of the senile dementias, the prevalence of
which is increasing rapidly, with a projected 14 million affected worldwide by 2025. The …

Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of
nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's …

The nicotinic receptors (nAChRs), which play a critical role in cognitive function, are
impaired early in the course of Alzheimer's disease (AD). We have previously demonstrated …

It has been recently shown that the Alzheimer's disease (AD) pathogenic peptide amyloid β1–
42 (Aβ1–42) binds to the α7 nicotinic acetylcholine receptor (α7nAChR) with high affinity …

Alzheimer's disease (AD) is a human neurological disorder characterized by an increasing
loss of cognitive function and the presence of extracellular neuritic plaques composed of the …

Alzheimer's disease (AD) is one of the major disabling and lethal diseases for aged
individuals worldwide. To date, there are more than 10 hypotheses proposed for AD …

Deterioration of the cortical cholinergic system is a leading neurochemical feature of
Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7 …

Although there is still no known effective preventative treatment or cure for Alzheimer's
disease (AD), the development of new drugs that target pathological features that appear …

Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the
loss of cholinergic neurons in the brain. The underlying mechanisms leading to these events …

Beta-amyloid (Aβ) has been recognized as an early trigger in the pathogenesis of
Alzheimer's disease (AD) leading to synaptic and cognitive impairments. Aβ can alter …