Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c‐Met system via hypoxia inducible factor‐1 in …
Y Kitajima, T Ide, T Ohtsuka, K Miyazaki - Cancer science, 2008 - Wiley Online Library
Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte
growth factor (HGF) into its active form. Our previous study demonstrated that tumor–stromal …
growth factor (HGF) into its active form. Our previous study demonstrated that tumor–stromal …
Tumor–stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c‐Met pathway
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - … journal of cancer, 2006 - Wiley Online Library
The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the …
progression. The interaction between stromal and cancer cells also contributes to the …
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells
L Tacchini, P Dansi, E Matteucci… - Carcinogenesis, 2001 - academic.oup.com
Hepatocyte growth factor (HGF), a multifunctional cytokine of mesenchymal origin, activates
the DNA binding of hypoxia inducible factor-1 (HIF-1) in the HepG2 cell line: the activated …
the DNA binding of hypoxia inducible factor-1 (HIF-1) in the HepG2 cell line: the activated …
The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - Annals of surgical …, 2007 - Springer
Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …
hypoxic microenvironment plays a crucial role in malignant progression. We previously …
Correlation between hypoxia and HGF/c-MET expression in the management of pancreatic cancer
Pancreatic cancer (PC) is very deadly and difficult to treat. The presence of hypoxia has
been shown to increase the probability of cancer developing and spreading. Pancreatic …
been shown to increase the probability of cancer developing and spreading. Pancreatic …
Hepatocyte growth factor signaling regulates transactivation of genes belonging to the plasminogen activation system via hypoxia inducible factor-1
L Tacchini, E Matteucci, C De Ponti… - Experimental cell …, 2003 - Elsevier
Hepatocyte growth factor (HGF) plays an important role in tumor growth and progression
also by regulating invasive/metastatic phenotype and angiogenesis. Here we report that a …
also by regulating invasive/metastatic phenotype and angiogenesis. Here we report that a …
[HTML][HTML] Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2
Hepatocyte growth factor (HGF) and its receptor c-Met were frequently deregulated in
hepatocellular carcinoma (HCC). Signaling pathways activated by HGF-c-Met are promising …
hepatocellular carcinoma (HCC). Signaling pathways activated by HGF-c-Met are promising …
Dominant-negative hypoxia-inducible factor-1α reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …
Regulation of glucose metabolism-related genes and VEGF by HIF-1α and HIF-1β, but not HIF-2α, in gastric cancer
Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of
target genes involved in crucial aspects of cancer development. This study investigated the …
target genes involved in crucial aspects of cancer development. This study investigated the …
Hypoxia-inducible factor-1alpha: molecular-targeted therapy for hepatocellular carcinoma
ZZ Dong, M Yao, L Wang, W Wu, X Gu… - Mini reviews in …, 2013 - ingentaconnect.com
Hypoxia-inducible factor (HIF)-1α is over-expressed in hepatocellular carcinoma (HCC) and
degraded by ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte …
degraded by ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte …