Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte
growth factor (HGF) into its active form. Our previous study demonstrated that tumor–stromal …

The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the …

Hepatocyte growth factor (HGF), a multifunctional cytokine of mesenchymal origin, activates
the DNA binding of hypoxia inducible factor-1 (HIF-1) in the HepG2 cell line: the activated …

Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …

Pancreatic cancer (PC) is very deadly and difficult to treat. The presence of hypoxia has
been shown to increase the probability of cancer developing and spreading. Pancreatic …

Hepatocyte growth factor (HGF) plays an important role in tumor growth and progression
also by regulating invasive/metastatic phenotype and angiogenesis. Here we report that a …

Hepatocyte growth factor (HGF) and its receptor c-Met were frequently deregulated in
hepatocellular carcinoma (HCC). Signaling pathways activated by HGF-c-Met are promising …

In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …

Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of
target genes involved in crucial aspects of cancer development. This study investigated the …

Hypoxia-inducible factor (HIF)-1α is over-expressed in hepatocellular carcinoma (HCC) and
degraded by ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte …