Globally, respiratory diseases are major cause of disability and mortality, and more
alarmingly, it disproportionately affects developing countries, which is largely attributed to …

The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

Reactive oxygen species (ROS) are products of normal cellular metabolism and are known
to act as second messengers. Under physiological conditions, ROS participate in …

As eukaryotic life evolved, so too did the need for a source of energy that meets the
requirements of complex organisms. Oxygen provides this vast potential energy source, but …

Reactive oxygen species (ROS), either derived from exogenous sources or overproduced
endogenously, can disrupt the body's antioxidant defenses leading to compromised redox …

Redox regulation participates in the control of various aspects of metabolism. Reactive
oxygen and nitrogen species participate in many reactions under physiological conditions …

Induction of oxidant stress either by raising ambient oxygen concentrations, adding toxins
that augment intracellular oxidant formation, generating ischemia followed by tissue …

Oxidative stress has many implications in the pathogenesis of lung diseases. In this review,
we provide an overview of Reactive Oxygen Species (ROS) and nitrogen (RNS) species and …

Reactive oxygen or nitrogen species (ROS, RNS) and oxidative stress in the respiratory
system increase the production of mediators of pulmonary inflammation and initiate or …

In the intracellular redox state (GSH/GSSG) the cell plays a key role in the regulation and
potentiation of the inflammatory response in lung cells. Glutathione and thioredoxin are the …