Survival benefits from reduced‐intensity conditioning in allogeneic stem cell transplantation for young lower‐risk MDS patients without significant comorbidities

SE Lee, YJ Kim, SA Yahng, BS Cho… - European Journal of …, 2011 - Wiley Online Library
Objective: The aim of this study was to determine the optimum conditioning intensity for
allogeneic stem cell transplantation (SCT) in young (age≤ 50), lower‐risk (INT‐1 by IPSS) …

Reduced-intensity conditioning followed by allogeneic hematopoietic cell transplantation in myeloid diseases

U Platzbecker, G Ehninger, N Schmitz… - Annals of …, 2003 - Springer
Within the past years, reduced or modified doses of chemotherapy or radiotherapy have
been widely studied for conditioning before allogeneic hematopoietic cell transplantation in …

[HTML][HTML] Results of a phase III randomized, multi-center study of allogeneic stem cell transplantation after high versus reduced intensity conditioning in patients with …

BL Scott, MC Pasquini, B Logan, J Wu, S Devine… - Blood, 2015 - Elsevier
Although reduced intensity conditioning (RIC) has a lower toxicity profile and lower
treatment related mortality (TRM), retrospective analyses have shown higher relapse rates …

Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from …

R Martino, A Henseler, M Van Lint, N Schaap… - Bone Marrow …, 2017 - nature.com
This study shows the long-term updated outcomes of a multicenter retrospective study which
analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent …

Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute …

F Baron, M Labopin, D Niederwieser, S Vigouroux… - Leukemia, 2012 - nature.com
This report investigated the impact of graft-versus-host disease (GVHD) on transplantation
outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem …

Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA …

R Martino, S Iacobelli, R Brand, T Jansen… - Blood, 2006 - ashpublications.org
In this multicenter retrospective study, the outcomes of 836 patients with myelodysplastic
syndrome (MDS) who underwent transplantation with a human leukocyte antigen (HLA) …

[HTML][HTML] Graft-versus-host disease induced graft-versus-leukemia effect: greater impact on relapse and disease-free survival after reduced intensity conditioning

D Weisdorf, MJ Zhang, M Arora, MM Horowitz… - Biology of Blood and …, 2012 - Elsevier
We studied graft-versus-host disease (GVHD) on relapse, transplant-related mortality (TRM),
disease-free survival (DFS), and overall survival (OS) after allogeneic transplantation for …

[HTML][HTML] Reduced intensity vs. standard conditioning followed by allogeneic stem cell transplantation for patients with MDS or secondary AML: a prospective …

N Kröger, R Brand, D Niederwieser, U Platzbecker… - Blood, 2014 - Elsevier
Introduction Retrospective studies in MDS/sAML suggest that reducing the intensity of the
conditioning regimen prior to allogeneic stem cell transplantation reduces the risk of non …

Reduced-intensity conditioning regimen combined with low-dose total body irradiation in the treatment of myelodysplastic syndrome

SE Lee, J Lim, SA Yahng, BS Cho, KS Eom, M Kim… - Acta …, 2011 - karger.com
Although reduced-intensity conditioning (RIC) has been increasingly used in patients with
myelodysplastic syndrome (MDS) to reduce transplant-related mortality, a high relapse rate …

[HTML][HTML] Myeloablative versus reduced-intensity hematopoietic cell transplantation in myelodysplastic syndromes: systematic review and meta-analysis

A Rashidi, MA Meybodi, W Cao, H Chu… - Biology of Blood and …, 2020 - Elsevier
In a systematic review and meta-analysis, we compared allogeneic transplant outcomes
after myeloablative conditioning (MAC) versus reduced-intensity conditioning (RIC) in …