Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Set2 co-transcriptionally methylates lysine 36 of histone H3 (H3K36), producing mono-, di-,
and trimethylation (H3K36me1/2/3). These modifications recruit or repel chromatin effector …

Histone modifications not only play important roles in regulating chromatin structure and
nuclear processes but also can be passed to daughter cells as epigenetic marks …

During development, covalent modification of both, histones and DNA contribute to the
specification and maintenance of cell identity. Repressive modifications are thought to …

Chromatin states must be maintained during cell proliferation to uphold cellular identity and
genome integrity. Inheritance of histone modifications is central in this process. However, the …

Intricate layers of regulation determine the unique gene expression profiles of a given cell
and, therefore, underlie the immense phenotypic diversity observed among cell types …

Histone lysine methylations have primarily been linked to selective recruitment of reader or
effector proteins that subsequently modify chromatin regions and mediate genome functions …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …