The interplay of histone modifications–writers that read
T Zhang, S Cooper, N Brockdorff - EMBO reports, 2015 - embopress.org
Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
Histone methylation: a dynamic mark in health, disease and inheritance
EL Greer, Y Shi - Nature Reviews Genetics, 2012 - nature.com
Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
Unique and shared roles for histone H3K36 methylation states in transcription regulation functions
Set2 co-transcriptionally methylates lysine 36 of histone H3 (H3K36), producing mono-, di-,
and trimethylation (H3K36me1/2/3). These modifications recruit or repel chromatin effector …
and trimethylation (H3K36me1/2/3). These modifications recruit or repel chromatin effector …
Readers of histone modifications
M Yun, J Wu, JL Workman, B Li - Cell research, 2011 - nature.com
Histone modifications not only play important roles in regulating chromatin structure and
nuclear processes but also can be passed to daughter cells as epigenetic marks …
nuclear processes but also can be passed to daughter cells as epigenetic marks …
[PDF][PDF] Mechanisms of transcriptional repression by histone lysine methylation
P Hublitz, M Albert, A Hfmpeters… - International Journal of …, 2009 - researchgate.net
During development, covalent modification of both, histones and DNA contribute to the
specification and maintenance of cell identity. Repressive modifications are thought to …
specification and maintenance of cell identity. Repressive modifications are thought to …
[HTML][HTML] Domain model explains propagation dynamics and stability of histone H3K27 and H3K36 methylation landscapes
Chromatin states must be maintained during cell proliferation to uphold cellular identity and
genome integrity. Inheritance of histone modifications is central in this process. However, the …
genome integrity. Inheritance of histone modifications is central in this process. However, the …
Trithorax and Polycomb group-dependent regulation: a tale of opposing activities
SJ Geisler, R Paro - Development, 2015 - journals.biologists.com
Intricate layers of regulation determine the unique gene expression profiles of a given cell
and, therefore, underlie the immense phenotypic diversity observed among cell types …
and, therefore, underlie the immense phenotypic diversity observed among cell types …
Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
Histone lysine methylations have primarily been linked to selective recruitment of reader or
effector proteins that subsequently modify chromatin regions and mediate genome functions …
effector proteins that subsequently modify chromatin regions and mediate genome functions …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
Signals and combinatorial functions of histone modifications
T Suganuma, JL Workman - Annual review of biochemistry, 2011 - annualreviews.org
Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …
signaling and for programmed gene expression in development. Posttranslational histone …