Mapping SARS-CoV-2 antigenic relationships and serological responses

SH Wilks, B Mühlemann, X Shen, S Türeli… - Science, 2023 - science.org
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic,
multiple variants escaping preexisting immunity emerged, causing reinfections of previously …

Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays

B Mühlemann, SH Wilks, L Baracco, M Bekliz… - Science Translational …, 2024 - science.org
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires
ongoing monitoring to judge the ability of newly arising variants to escape the immune …

Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history

W Wang, S Lusvarghi, R Subramanian, NJ Epsi… - Cell host & …, 2022 - cell.com
The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we
collected 201 serum samples from persons with a single infection or multiple vaccine …

Omicron BA. 1 and BA. 2 are antigenically distinct SARS-CoV-2 variants

AZ Mykytyn, M Rissmann, A Kok, ME Rosu, D Schipper… - BioRxiv, 2022 - biorxiv.org
The emergence and rapid spread of SARS-CoV-2 variants may impact vaccine efficacy
significantly. The Omicron variant termed BA. 2, which differs genetically substantially from …

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

A Pegu, SE O'Connell, SD Schmidt, S O'Dell… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations may diminish
vaccine-induced protective immune responses, particularly as antibody titers wane over …

Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …

Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California

V Servellita, MK Morris, A Sotomayor-Gonzalez… - Nature …, 2022 - nature.com
Associations between vaccine breakthrough cases and infection by different SARS
coronavirus 2 (SARS-CoV-2) variants have remained largely unexplored. Here we analysed …

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

E Shrock, E Fujimura, T Kula, RT Timms, IH Lee… - Science, 2020 - science.org
INTRODUCTION A systematic characterization of the humoral response to severe acute
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …

SARS-CoV-2 within-host diversity and transmission

KA Lythgoe, M Hall, L Ferretti, M de Cesare… - Science, 2021 - science.org
INTRODUCTION Genome sequencing at an unprecedented scale during the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is helping to track spread of …

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

CJ Reynolds, JM Gibbons, C Pade, KM Lin… - Science, 2022 - science.org
The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is …