The pathophysiology of dyspnea and exercise intolerance in chronic obstructive pulmonary disease

DE O'Donnell, MD James, KM Milne… - Clinics in chest …, 2019 - chestmed.theclinics.com
In the last American Thoracic Society (ATS) statement, dyspnea was defined as “a subjective
experience of breathing discomfort that consists of qualitatively distinct sensations that vary …

The link between reduced inspiratory capacity and exercise intolerance in chronic obstructive pulmonary disease

DE O'Donnell, AF Elbehairy, KA Webb… - Annals of the American …, 2017 - atsjournals.org
Low inspiratory capacity (IC), chronic dyspnea, and reduced exercise capacity are
inextricably linked and are independent predictors of increased mortality in chronic …

Activity-related dyspnea in chronic obstructive pulmonary disease: physical and psychological consequences, unmet needs, and future directions

NA Hanania, DE O'Donnell - International journal of chronic …, 2019 - Taylor & Francis
Dyspnea is a distressing, debilitating, and near-ubiquitous symptom affecting patients with
COPD. In addition to the functional consequences of dyspnea, which include activity …

Exercise capacity in chronic obstructive pulmonary disease: mechanisms of limitation

V Pepin, D Saey, L Laviolette… - COPD: Journal of Chronic …, 2007 - Taylor & Francis
Patients with chronic obstructive pulmonary disease (COPD) are often caught in a
downward spiral that progresses from expiratory flow limitation to poor quality of life and …

Mechanisms and measures of exercise intolerance in chronic obstructive pulmonary disease

L Nici - Clinics in chest medicine, 2000 - Elsevier
Impaired exercise tolerance is a prominent feature of chronic obstructive pulmonary disease
(COPD). 46, 59 Patients with COPD demonstrate widely variable exercise capacities …

Examining the role of activity, exercise, and pharmacology in mild COPD

DE O'Donnell, KB Gebke - Postgraduate medicine, 2014 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide and, although it is a preventable and treatable disease, it often remains …

Mechanisms of activity-related dyspnea in pulmonary diseases

DE O'Donnell, J Ora, KA Webb, P Laveneziana… - Respiratory physiology …, 2009 - Elsevier
Progressive activity-related dyspnea dominates the clinical presentation of patients afflicted
by chronic obstructive and restrictive lung diseases. This symptom invariably leads to activity …

The systemic nature of chronic lung disease

RA Evans, MDL Morgan - Clinics in chest medicine, 2014 - chestmed.theclinics.com
Dyspnea on exertion is the commonest symptom of chronic lung disease. Chronic
obstructive pulmonary disease (COPD) is the commonest chronic lung disease, and serves …

Impacting patient-centred outcomes in COPD: breathlessness and exercise tolerance

DE O'Donnell - European Respiratory Review, 2006 - Eur Respiratory Soc
The physiological hallmark of chronic obstructive pulmonary disease (COPD) is expiratory
flow limitation. However, it is the resultant air trapping and associated increases in lung …

Pathophysiology of dyspnea in COPD

A Anzueto, M Miravitlles - Postgraduate medicine, 2017 - Taylor & Francis
Dyspnea refers to the sensation of breathlessness, shortness of breath, or difficulty breathing
that is commonly observed in patients with respiratory and cardiac disease. In the United …