Background Recent hypertension guidelines have reversed previous recommendations for
lower blood pressure targets in high-risk patients, such as those with cardiovascular …

Background Guidelines recommend intensive blood pressure (BP) lowering in patients at
high risk. While placebo-controlled trials have demonstrated 22% reductions in coronary …

Background The benefits of blood pressure lowering treatment for prevention of
cardiovascular disease are well established. However, the extent to which these effects …

Importance Trials in patients with hypertension have demonstrated that intensive blood
pressure (BP) lowering reduces the risk of cardiovascular disease and all-cause mortality …

Methods: Among randomized-controlled trials (RCTs) of BP lowering treatment between
1966 and 2015, 16 (52 235 patients) compared more vs. less intense treatment and fulfilled …

Background: Recent guidelines suggest lowering the target blood pressure for patients with
chronic kidney disease, although the strength of evidence for this suggestion has been …

Several randomized trials compared a more versus less intensive blood pressure–lowering
strategy on the risk of major cardiovascular events and death. Cumulative meta-analyses …

Background: Type 2 diabetes mellitus is associated with an increased risk of hypertension,
and cardiovascular and renal disease, and it has been recommended that management of …

Background The effects of pharmacological blood pressure lowering at normal or high-
normal blood pressure ranges in people with or without pre-existing cardiovascular disease …

Background In a previously reported randomized trial of standard and intensive systolic
blood-pressure control, data on some outcome events had yet to be adjudicated and post …