The sigma-2 receptor has been cloned and identified as Tmem97, which is a
transmembrane protein involved in intracellular Ca 2+ regulation and cholesterol …

Sigma receptors modulate nociception, offering a potential therapeutic target to treat pain,
but relatively little is known regarding the role of sigma-2 receptors (S2R) in nociception. The …

The synthesis and sigma-1 receptor (σ 1 R) antagonist activity of a new series of 3, 4-dihydro-
2 (1H)-quinolinone derivatives are reported. The new compounds were evaluated in vitro in …

A novel series of sigma (σ) receptor ligands based on an alkoxyisoxazole scaffold has been
designed and synthesized. Preliminary receptor binding assays identified highly potent (K i< …

Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without
the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of …

We designed and synthesized a novel series of piperidine propionamide derivatives as
potent sigma-1 (σ 1) receptor antagonists and mu (μ) opioid receptor agonists, and …

The design and synthesis of a series of 2, 7-diazaspiro [4.4] nonane derivatives as potent
sigma receptor (SR) ligands, associated with analgesic activity, are the focus of this work. In …

The discovery and synthesis of a new series of pyrimidines as potent sigma-1 receptor (σ1R)
antagonists, associated with pharmacological antineuropathic pain activity, are the focus of …

A series of novel indole-based analogs were prepared and their affinities for sigma
receptors were determined using in vitro radioligand binding assays. The results of this …

The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ 1 R)
antagonist, has been explored in experimental neuropathic pain, but not in inflammatory …