The three-dimensional configuration of DNA is integral to all nuclear processes in
eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide …

Chromosome conformation capture approaches have shown that interphase chromatin is
partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized topological …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

Chromatin is organized in the nucleus via CTCF loops and compartmental domains. Here,
we compare different cell types to identify distinct paradigms of compartmental domain …

Chromosome conformation capture (3C) methods measure DNA contact frequencies based
on nuclear proximity ligation, to uncover in vivo genomic folding patterns. 4C–seq is a …

Technological developments and intense research over the last years have led to a better
understanding of the 3D structure of the genome and its influence on genome function …

Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …

The three-dimensional genomic structure plays a critical role in gene expression, cellular
differentiation, and pathological conditions. It is pivotal to elucidate fine-scale chromatin …

How chromosomes are organized within the tridimensional space of the nucleus and how
can this organization affect genome function have been long-standing questions on the path …

Although population-level analyses revealed significant roles for CTCF and cohesin in
mammalian genome organization, their contributions at the single-cell level remain …