Genetics of COPD
NA Molfino - Chest, 2004 - Elsevier
COPD is a complex mix of signs and symptoms in patients with chronic bronchitis and
emphysema, diseases that largely result from cigarette smoking. Not all smokers, however …
emphysema, diseases that largely result from cigarette smoking. Not all smokers, however …
Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE)
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and not well
understood. The forced expiratory volume in one second is used for the diagnosis and …
understood. The forced expiratory volume in one second is used for the diagnosis and …
Chronic obstructive pulmonary disease: CT quantification of airways disease
M Hackx, AA Bankier, PA Gevenois - Radiology, 2012 - pubs.rsna.org
Chronic obstructive pulmonary disease (COPD) is an increasing cause of morbidity and
mortality worldwide and results in substantial social and economic burdens. COPD is a …
mortality worldwide and results in substantial social and economic burdens. COPD is a …
The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study
HO Coxson, A Dirksen, LD Edwards… - The lancet Respiratory …, 2013 - thelancet.com
Background Emphysema is a key contributor to airflow limitation in chronic obstructive
pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the …
pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the …
Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
Background Numerous studies have demonstrated associations between genetic markers
and COPD, but results have been inconsistent. One reason may be heterogeneity in disease …
and COPD, but results have been inconsistent. One reason may be heterogeneity in disease …
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …
but the individual variants that have been identified have small effects. We hypothesised that …
[HTML][HTML] COPDGene® 2019: redefining the diagnosis of chronic obstructive pulmonary disease
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of
morbidity and mortality. Present-day diagnostic criteria are largely based solely on …
morbidity and mortality. Present-day diagnostic criteria are largely based solely on …
Gender differences in the severity of CT emphysema in COPD
Background The hallmark of COPD is airflow obstruction, but this can develop on the basis
of airway disease, emphysema, or both. There are gender differences in the natural history …
of airway disease, emphysema, or both. There are gender differences in the natural history …
Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive …
OBJECTIVE. This study evaluates the relationships between quantitative CT (QCT) and
spirometric measurements of disease severity in cigarette smokers with and without chronic …
spirometric measurements of disease severity in cigarette smokers with and without chronic …
Five-year progression of emphysema and air trapping at CT in smokers with and those without chronic obstructive pulmonary disease: results from the COPDGene …
E Pompe, M Strand, EM van Rikxoort, EA Hoffman… - Radiology, 2020 - pubs.rsna.org
Background CT is used to quantify abnormal changes in the lung parenchyma of smokers
that might overlap chronic obstructive pulmonary disease (COPD), but studies on the …
that might overlap chronic obstructive pulmonary disease (COPD), but studies on the …