Nanoparticles for generating antigen-specific T cells for immunotherapy
T cell therapy shows promise as an immunotherapy in both immunostimulatory and
immunosuppressive applications. However, the forms of T cell-based therapy that are …
immunosuppressive applications. However, the forms of T cell-based therapy that are …
Tailoring the physicochemical properties of nanomaterials for immunomodulation
Immunomodulation is poised to revolutionize the treatment of cancer, autoimmune diseases,
and many other inflammation-related disorders. The immune system in these conditions can …
and many other inflammation-related disorders. The immune system in these conditions can …
Exploiting lymphatic transport and complement activation in nanoparticle vaccines
Abstract Antigen targeting,,,, and adjuvancy schemes, that respectively facilitate delivery of
antigen to dendritic cells and elicit their activation have been explored in vaccine …
antigen to dendritic cells and elicit their activation have been explored in vaccine …
Tolerogenic nanoparticles suppress central nervous system inflammation
Therapeutic approaches for the induction of immune tolerance remain an unmet clinical
need for the treatment of autoimmune diseases, including multiple sclerosis (MS). Based on …
need for the treatment of autoimmune diseases, including multiple sclerosis (MS). Based on …
Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation
Allogeneic cell therapies have either proven effective or have great potential in numerous
applications, though the required systemic, life-long immunosuppression presents …
applications, though the required systemic, life-long immunosuppression presents …
Skin Dendritic Cell Targeting via Microneedle Arrays Laden with Antigen-Encapsulated Poly-d,l-lactide-co-Glycolide Nanoparticles Induces Efficient Antitumor and …
M Zaric, O Lyubomska, O Touzelet, C Poux… - ACS …, 2013 - ACS Publications
The efficacious delivery of antigens to antigen-presenting cells (APCs), in particular, to
dendritic cells (DCs), and their subsequent activation remains a significant challenge in the …
dendritic cells (DCs), and their subsequent activation remains a significant challenge in the …
Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists
C Stavnsbjerg, E Christensen, R Münter… - Journal of Controlled …, 2022 - Elsevier
Systemic administration of toll-like receptor (TLR) agonists have demonstrated impressive
preclinical results as an anti-cancer therapy due to their potent innate immune-stimulatory …
preclinical results as an anti-cancer therapy due to their potent innate immune-stimulatory …
B cells are the dominant antigen-presenting cells that activate naive CD4+ T cells upon immunization with a virus-derived nanoparticle antigen
B cells can present antigens to CD4+ T cells, but it is thought that dendritic cells (DCs) are
the primary initiators of naive CD4+ T cell responses. Nanoparticles, including virus-like …
the primary initiators of naive CD4+ T cell responses. Nanoparticles, including virus-like …
Multivalent nanomaterials: learning from vaccines and progressing to antigen-specific immunotherapies
BL Hartwell, L Antunez, BP Sullivan, S Thati… - Journal of …, 2015 - Elsevier
Continued development of multivalent nanomaterials has provided opportunities for the
advancement of antigen-specific immunotherapies. New insights emerge when considering …
advancement of antigen-specific immunotherapies. New insights emerge when considering …
Biodegradable nanoparticles as vaccine adjuvants and delivery systems: regulation of immune responses by nanoparticle-based vaccine
T Akagi, M Baba, M Akashi - Polymers in nanomedicine, 2012 - Springer
Polymeric nano-and microparticles have recently been shown to possess significant
potential as drug delivery systems. In particular, the use of biodegradable polymeric …
potential as drug delivery systems. In particular, the use of biodegradable polymeric …