Protein subunit vaccines offer important potential advantages over live vaccine vectors but
generally elicit weaker and shorter-lived cellular immune responses. Here we investigate …

Nanoparticle-based drug delivery systems have been synthesized from a wide array of
materials. The therapeutic success of these platforms hinges upon their ability to favorably …

Background Helper T cell activity is dysregulated in a number of diseases including those
associated with rheumatic autoimmunity. Treatment options are limited and usually consist …

Development of vaccines in autoimmune diseases has received wide attention over the last
decade. However, many vaccines showed limited clinical efficacy. To enhance vaccine …

An appropriate delivery system can improve the immune effects of antigens against various
infections or tumors. Antigen-presenting cells (APCs) are specialized to capture and process …

Polymeric nanoparticles (NPs) composed of poly (lactic-co-glycolic acid)(PLGA) have found
success in modulating antigen (Ag)-specific T cell responses for the treatment multiple …

Nanoparticle delivery of subunit vaccines may increase vaccine efficacy, leading to a wide
variety of safe and effective vaccines beyond those available through dosing inactivated or …

Dendritic-cell (DC) targeted antigen delivery systems hold promise for enhancing vaccine
efficacy and delivery of therapeutics. However, it is not known how the number and density …

Highlights•Vast potentials of combining nanoparticles with immune therapy.•Nanoparticles
as adjuvants or carriers for vaccination and targeted therapies.•Disease therapies using …

Antigen-specific treatments are highly desirable for autoimmune diseases in contrast to
treatments which induce systemic immunosuppression. A novel antigen-specific therapy has …