The role of eosinophils in bullous pemphigoid: a developing model of eosinophil pathogenicity in mucocutaneous disease

KT Amber, M Valdebran, K Kridin, SA Grando - Frontiers in Medicine, 2018 - frontiersin.org
Bullous pemphigoid (BP) is an autoimmune blistering disease which carries a significant
mortality and morbidity. While historically BP has been characterized as an IgG driven …

The intersection of IgE autoantibodies and eosinophilia in the pathogenesis of bullous pemphigoid

KN Messingham, TP Crowe, JA Fairley - Frontiers in immunology, 2019 - frontiersin.org
Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by
autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are …

[HTML][HTML] Eosinophils mediate tissue injury in the autoimmune skin disease bullous pemphigoid

L Lin, BJ Hwang, DA Culton, N Li, S Burette… - Journal of Investigative …, 2018 - Elsevier
Eosinophils are typically associated with unique inflammatory settings, including allergic
inflammation and helminth infections. However, new information suggests that eosinophils …

Evidence for a role of eosinophils in blister formation in bullous pemphigoid

E de Graauw, C Sitaru, M Horn, L Borradori, S Yousefi… - Allergy, 2017 - Wiley Online Library
Background Bullous pemphigoid (BP) is an autoimmune bullous disease of the skin
characterized by subepidermal blister formation due to tissue‐bound and circulating …

Human eosinophils express the high affinity IgE receptor, FcεRI, in bullous pemphigoid

KN Messingham, HM Holahan, AS Frydman… - PloS one, 2014 - journals.plos.org
Bullous pemphigoid (BP) is an autoimmune blistering disease mediated by autoantibodies
targeting BP180 (type XVII collagen). Patient sera and tissues typically have IgG and IgE …

Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome

D Giusti, G Gatouillat, S Le Jan, J Plée, P Bernard… - Scientific Reports, 2017 - nature.com
Bullous Pemphigoid (BP) is an inflammatory rare autoimmune bullous dermatosis, which
outcome cannot be predicted through clinical investigations. Eosinophils are the main …

Peripheral eosinophilia in bullous pemphigoid: prevalence and influence on the clinical manifestation

K Kridin - British Journal of Dermatology, 2018 - academic.oup.com
Background Peripheral eosinophilia has been reported in 50–60% of patients with bullous
pemphigoid (BP) and correlated positively with disease severity. Objectives To establish an …

Elevated levels of eotaxin and interleukin‐5 in blister fluid of bullous pemphigoid: correlation with tissue eosinophilia

M Wakugawa, K Nakamura, H Hino… - British Journal of …, 2000 - academic.oup.com
Background Bullous pemphigoid (BP) often provokes blood and tissue eosinophilia, which
suggests that some chemoattractants modulate the eosinophil infiltration in BP. Eotaxin, a …

IgE autoreactivity in bullous pemphigoid: eosinophils and mast cells as major targets of pathogenic immune reactants

PC Freire, CH Muñoz, G Stingl - British Journal of Dermatology, 2017 - academic.oup.com
Background Bullous pemphigoid (BP) is an autoimmune disease characterized by tense
blisters that are usually preceded by urticarial eruptions. Affected patients exhibit IgG and/or …

Unraveling the significance of IgE autoantibodies in organ-specific autoimmunity: lessons learned from bullous pemphigoid

KAN Messingham, HM Holahan, JA Fairley - Immunologic research, 2014 - Springer
Bullous pemphigoid (BP), a cutaneous autoimmune blistering disease, has provided a
useful model to elucidate a role for IgE in autoimmunity. IgE antibodies specific for the …