Human and animal laboratory studies show that females and males respond differently to
drugs and that drug administration during adolescence leads to different behavioral effects …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

Cocaine conditioned place preference (CPP) is more persistent in food-restricted than ad
libitum fed rats. This study assessed whether food restriction acts during conditioning and/or …

THE conditioned place preference (CPP) induced by cocaine 2.5 mg/kg was measured in
rats pre-exposed to ethanol (14 days with only 10% v/v ethanol followed by a free choice …

Previous studies have shown that adolescent exposure to cocaine increases drug use in
adulthood, albeit incubation of cocaine seeking was found to be attenuated in rats trained to …

Differences in cocaine self-administration can be attributed to differences in the rewarding
value that cocaine has for the individual. An ongoing debate, however, exists whether a high …

High locomotor response to novelty is associated with ease of drug self-administration but
does not predict greater place-conditioning effects of drugs. Yet, the latter reflects context …

In rodents, only a single dose of cocaine or amphetamine is required to cause a marked
increase in extracellular dopamine, induce hyperlocomotion and cause persistent plasticity …

In three separate place preference conditioning (PPC) experiments, groups of rats were
exposed to different modes of receiving cocaine: IP cocaine doses (7.5 mg/kg), PO cocaine …

The purpose of this study was to determine whether chronic exercise alters sensitivity to the
conditioned rewarding effects of cocaine. Female rats were obtained at weaning and …