Rationale: In animal models, cocaine cues contribute to the development of conditioned
responses to the psychomotor stimulating and rewarding effects of the drug. Objectives: In …

Abstract Rationale Intermittent Access (IntA) cocaine self-administration, which models
intermittent patterns of cocaine use in humans during the transition to addiction, is especially …

After chronic exposure to psychostimulants or opiates, self-administration or conditioned
place preference with either class is increased (sensitized). Cross-sensitization of …

Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is
considered to predict the response of animals to drugs of abuse and, thus, allow “drug …

In two conditioning experiments, identical procedures (previously shown to produce place
preferences for a cocaine-paired environment) were used to assess dopaminergic and …

The environment in which cocaine is experienced becomes associated with the effects of the
drug and can then elicit cocaine craving. This study examined whether the hippocampus is …

Conditioned place preference (CPP), a commonly used model for studying the role of
contextual cues in drug reward and drug seeking, was employed to explore possible …

Classical conditioning and behavioural sensitisation of motor activity induced with cocaine
(10 mg/kg, ip) were examined using an unbiased two-compartment conditioned place …

A key component of combating substance use disorders is understanding the neural
mechanisms that support drug reward. Tasks such as self-administration assess the …

A significant problem in treating cocaine dependence is craving-induced relapse elicited by
inadvertent (ie, passive) exposure to cocaine-paired stimuli. Extinction/reinstatement of …