Tumor erosion and metastasis can invade surrounding tissues, damage nerves, and
sensitize the peripheral primary receptors, inducing pain, which can potentially worsen the …

Neuropathic pain (NPP) is a common syndrome associated with most forms of cancer, which
poses a serious threat to human health. NPP may persist even after the nociceptive …

Schwann cells (SCs) are the most abundant cell type in the nerves in the peripheral nervous
system and compose a family of subtypes that are endowed with a variety of different …

Neuropathic pain caused by nerve injury or disease remains a major challenge for modern
medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are …

The tumor microenvironment (TME), which is composed of various cell components and
signaling molecules, plays an important role in the occurrence and progression of tumors …

Neuropathic pain (NP) is caused by a lesion or a condition that affects the somatosensory
system. Pathophysiologically, NP can be ascribed to peripheral and central sensitization …

Neuropathic pain is a complex, chronic pain state that is heterogeneous in nature and
caused by the consequence of a lesion or disease affecting the somatosensory system …

Although macrophages (MΦ) are known to play a central role in neuropathic pain, their
contribution to cancer pain has not been established. Here we report that depletion of sciatic …

Nerves enable cancer progression, as cancers have been shown to extend along nerves
through the process of perineural invasion, which carries a poor prognosis. Furthermore, the …

Cancerous cells must cooperate with the surrounding stroma and non-malignant cells within
the microenvironment to support the growth and invasion of the tumor. The nervous system …