Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …

We previously reported that substituted 4-aminoquinolines with a phenyl ether substituent at
the 7-position of the quinoline ring and the capability of intramolecular hydrogen bonding …

Quinazolines have long been known to exert varied pharmacologic activities that make them
suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014 …

Hybrid compounds may play a critical role in the context of the malaria eradication agenda,
which will benefit from therapeutic tools active against the symptomatic erythrocytic stage of …

We describe the synthesis and antimalarial activities of 1H-1, 2, 3-triazole tethered 7-
chloroquinoline-isatin hybrids. Activity against cultured parasites was dependent on the C-5 …

The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …

Malaria still threatens half the globe population despite successful Artemisinin-based
combination therapy. One of the reasons for our inability to eradicate malaria is the …

The development of new antimalarial compounds remains a pivotal part of the strategy for
malaria elimination. Recent large-scale phenotypic screens have provided a wealth of …

A series of 2-pyrazolyl quinolones has been designed and synthesized in 5–7 steps to
optimize for both in vitro antimalarial potency and various in vitro drug metabolism and …

Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs
are urgently required at an affordable price. We report herein the design, synthesis, and …