In the present study we have synthesized a new class of 4-aminoquinolines and evaluated
against Plasmodium falciparum in vitro (3D7-sensitive strain & K1-resistant strain) and …

Molecular hybridization of privileged scaffolds may generate novel antiplasmodial
chemotypes that display superior biological activity and delay drug resistance. In the present …

Malaria is a very destructive and lethal parasitic disease that causes significant mortality
worldwide, resulting in the loss of millions of lives annually. It is an infectious disease …

Putting a stop to malaria: Phenotypic screening against malaria parasites, hit identification,
and efficient lead optimization have delivered the preclinical candidate antimalarial …

Malaria is a major public health problem all over the world, particularly in tropical and
subtropical countries due to the development of resistance and most deadly infection is …

Malaria deaths have been decreasing over the last 10–15 years, with global mortality rates
having fallen by 47% since 2000. While the World Health Organization (WHO) recommends …

The continued proliferation of malaria throughout temperate and tropical regions of the world
has promoted a push for more efficacious treatments to combat the disease. Unfortunately …

Twenty-seven 7-chloroquinolinotriazole derivatives with different substituents in the triazole
moiety were synthesized via copper-catalyzed cycloaddition (CuAAC) click chemistry …

The emergence of drug resistance against the frontline antimalarials is a major challenge in
the treatment of malaria. In view of emerging reports on drug-resistant strains of Plasmodium …

(+)-Mahanimbine (1) is a carbazole alkaloid isolated from Murraya koenigii. It undergoes
rearrangements under thermal, photolytic, or acidic conditions and is transformed into …