In the present study we have synthesized a new class of 4-aminoquinoline derivatives via
replacement of the diethylamine functionality of chloroquine (CQ) with acyclic and/or cyclic …

A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide
derivatives as a novel antimalarial scaffold. Structure–activity relationship studies led to …

A class of hybrid molecules consisting of 4-aminoquinoline and pyrimidine were synthesized
and tested for antimalarial activity against both chloroquine (CQ)-sensitive (D6) and …

Background: Malaria is a disease causing millions of victims every year and requires new
drugs, often due to parasitic strain mutations. Thus, the search for new molecules that …

The control of malaria is challenged by drug resistance, and new antimalarial drugs are
needed. New drug discovery efforts include consideration of hybrid compounds as potential …

The emergence of resistance to first-line antimalarial drugs calls for the development of new
therapies for drug-resistant malaria. The efficacy of quinoline-based antimalarial drugs has …

A series of 34 1, 2, 3-triazole-naphthoquinone conjugates were synthesized via copper-
catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity …

In recent times, the novel concept of generating hybrid molecules by pharmacophoric
hybridisation approach is fast becoming an alternative to other existing strategies of drug …

Novel bisquinoline derivatives of tetraazamacrocyclic compounds, namely 4, 10-bis (7-
chloroquinoline)-1, 4, 7, 10-tetraazacyclododecane (1, Scheme 1); 4, 10-bis (7 …

Malaria is responsible for nearly one million deaths annually, and the increasing prevalence
of multi-resistant strains of Plasmodium falciparum poses a great challenge to controlling the …