How do dual long-acting bronchodilators prevent exacerbations of chronic obstructive pulmonary disease?

KM Beeh, PR Burgel, FME Franssen… - American journal of …, 2017 - atsjournals.org
Decreasing the frequency and severity of exacerbations is one of the main goals of
treatment for patients with chronic obstructive pulmonary disease. Several studies have …

[HTML][HTML] Optimizing bronchodilation in the prevention of COPD exacerbations

M Miravitlles, A Anzueto, JR Jardim - Respiratory Research, 2017 - Springer
The natural disease course of chronic obstructive pulmonary disease (COPD) is often
punctuated by exacerbations: acute events of symptom worsening associated with …

[HTML][HTML] The role of bronchodilators in preventing exacerbations of chronic obstructive pulmonary disease

KM Beeh - Tuberculosis and Respiratory Diseases, 2016 - ncbi.nlm.nih.gov
Bronchodilators are the cornerstone of symptomatic chronic obstructive pulmonary disease
(COPD) treatment. They are routinely recommended for symptom reduction, with a …

Comparative Effectiveness of Long‐Acting Beta2‐Agonist Combined with a Long‐Acting Muscarinic Antagonist or Inhaled Corticosteroid in Chronic Obstructive …

JC Samp, MJ Joo, GT Schumock… - … : The Journal of …, 2017 - Wiley Online Library
Introduction Several dual bronchodilator fixed‐dose inhaler medications were recently
approved for the treatment of chronic obstructive pulmonary disease (COPD). These …

The role of bronchodilator treatment in the prevention of exacerbations of COPD

JA Wedzicha, M Decramer… - European Respiratory …, 2012 - Eur Respiratory Soc
Exacerbations of chronic obstructive pulmonary disease (COPD) are natural events in the
progression of the disease, and are characterised by acute worsening of symptoms …

A pooled analysis of mortality in patients with COPD receiving dual bronchodilation with and without additional inhaled corticosteroid

M Miravitlles, K Verhamme, PMA Calverley… - … journal of chronic …, 2022 - Taylor & Francis
Background Recent studies report a lower mortality rate during treatment with long-acting
muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA)/inhaled corticosteroid (ICS) …

Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis

EJ Mills, E Druyts, I Ghement, MA Puhan - Clinical epidemiology, 2011 - Taylor & Francis
Background: Most patients with moderate and severe chronic obstructive pulmonary disease
(COPD) receive long-acting bronchodilators (LABA) for symptom control. It is, however …

Risk of Cardiovascular and Cerebrovascular Events in COPD Patients Treated With Long-Acting β2-Agonist Combined With a Long-Acting Muscarinic or Inhaled …

JC Samp, MJ Joo, GT Schumock… - Annals of …, 2017 - journals.sagepub.com
Background: The recent approval of several fixed-dose combination long-acting β2-agonist
(LABA) and long-acting muscarinic antagonist (LAMA) products has increased the use of …

Pharmacology of novel treatments for COPD: are fixed dose combination LABA/LAMA synergistic?

D Spina - European clinical respiratory journal, 2015 - Taylor & Francis
Bronchodilators are mainstay for the symptomatic treatment of chronic obstructive pulmonary
disease (COPD) and the introduction of long-acting bronchodilators has led to an …

Investigating new standards for prophylaxis in reduction of exacerbations—the INSPIRE study methodology

T Seemungal, R Stockley, P Calverley… - COPD: Journal of …, 2007 - Taylor & Francis
Bronchodilators, including long-acting β2-adrenoceptor agonists and anticholinergic
bronchodilators, are effective in the treatment of chronic obstructive pulmonary disease …