A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss
Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and
widespread cortical neuronal loss. The “amyloid cascade hypothesis” posits that cerebral …
widespread cortical neuronal loss. The “amyloid cascade hypothesis” posits that cerebral …
Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions
TA Kokjohn, AE Roher - Alzheimer's & Dementia, 2009 - Elsevier
Transgenic (Tg) mice that overexpress mutant familial Alzheimer's disease (AD) amyloid
precursor protein (APP) genes have contributed to an understanding of dementia pathology …
precursor protein (APP) genes have contributed to an understanding of dementia pathology …
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment
In the last decade, multiple lines of transgenic APP overexpressing mice have been created
that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the …
that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the …
Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in …
H Oakley, SL Cole, S Logan, E Maus… - Journal of …, 2006 - Soc Neuroscience
Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2)
increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD) …
increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD) …
Mouse models of Alzheimer's disease: insight into treatment
DC German, AJ Eisch - Reviews in the Neurosciences, 2004 - degruyter.com
Mice overexpressing mutant Alzheimer's disease (AD)-related proteins exhibit many of the
neuropathological and behavioral features of the human disease. Transgenic animals have …
neuropathological and behavioral features of the human disease. Transgenic animals have …
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
C Schmitz, BPF Rutten, A Pielen, S Schäfer… - The American journal of …, 2004 - Elsevier
According to the “amyloid hypothesis of Alzheimer's disease,” β-amyloid is the primary
driving force in Alzheimer's disease pathogenesis. Despite the development of many …
driving force in Alzheimer's disease pathogenesis. Despite the development of many …
Overview of transgenic mouse models for Alzheimer's disease
A Myers, P McGonigle - Current protocols in neuroscience, 2019 - Wiley Online Library
This review describes several transgenic mouse models of Alzheimer's disease (AD), a
devastating neurodegenerative disorder that causes progressive cognitive decline and is …
devastating neurodegenerative disorder that causes progressive cognitive decline and is …
Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain
TM Wengenack, S Whelan, GL Curran, KE Duff… - Neuroscience, 2000 - Elsevier
The development of transgenic mice has created new opportunities for the generation of
animal models of human neurodegenerative diseases where previously there was no …
animal models of human neurodegenerative diseases where previously there was no …
Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
R Radde, T Bolmont, SA Kaeser, J Coomaraswamy… - EMBO …, 2006 - embopress.org
We have generated a novel transgenic mouse model on a C57BL/6J genetic background
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …
[HTML][HTML] Probing the biology of Alzheimer's disease in mice
KH Ashe, KR Zahs - Neuron, 2010 - cell.com
Alzheimer's disease (AD), the most common cause of dementia among the elderly, may
either represent the far end of a continuum that begins with age-related memory decline or a …
either represent the far end of a continuum that begins with age-related memory decline or a …
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