Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and
widespread cortical neuronal loss. The “amyloid cascade hypothesis” posits that cerebral …

Transgenic (Tg) mice that overexpress mutant familial Alzheimer's disease (AD) amyloid
precursor protein (APP) genes have contributed to an understanding of dementia pathology …

In the last decade, multiple lines of transgenic APP overexpressing mice have been created
that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the …

Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2)
increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD) …

Mice overexpressing mutant Alzheimer's disease (AD)-related proteins exhibit many of the
neuropathological and behavioral features of the human disease. Transgenic animals have …

According to the “amyloid hypothesis of Alzheimer's disease,” β-amyloid is the primary
driving force in Alzheimer's disease pathogenesis. Despite the development of many …

This review describes several transgenic mouse models of Alzheimer's disease (AD), a
devastating neurodegenerative disorder that causes progressive cognitive decline and is …

The development of transgenic mice has created new opportunities for the generation of
animal models of human neurodegenerative diseases where previously there was no …

We have generated a novel transgenic mouse model on a C57BL/6J genetic background
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …

Alzheimer's disease (AD), the most common cause of dementia among the elderly, may
either represent the far end of a continuum that begins with age-related memory decline or a …