Different studies have confirmed that P2X purinergic receptors play a key role in
inflammation. Activation of P2X purinergic receptors can release inflammatory cytokines and …

Neuroinflammation limits tissue damage in response to pathogens or injury and promotes
repair. There are two stages of inflammation, initiation and resolution. P2X receptors are …

Different studies have confirmed P2X7 receptor-mediated inflammatory mediators play a key
role in the development of pain. P2X7 receptor activation can induce the development of …

Abstract Background ATP-gated P2X7 is a non-selective cation channel, which participates
in a wide range of cellular functions as well as pathophysiological processes including …

Post-ischemic inflammation is an essential step in the progression of brain ischemia injury.
P2X4 receptors are the predominant purinergic P2X receptor subtypes expressed on …

Extracellular nucleotides have been recognized as important mediators of activation,
triggering multiple responses via plasma membrane receptors known as P2 receptors. P2 …

Abstract P2X7 receptor (P2X7R) is an ATP-gated non-selective cation channel which
mediates ATP-induced inflammation in macrophages. Transient receptor potential (TRP) …

P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the
extensive release of ATP induces sustained P2X7 receptor activation, culminating in …

The P2X7 purinergic receptor is a ligand‐gated cation channel expressed on leukocytes
including microglia. This study aimed to determine if P2X7 activation induces the uptake of …

The adenosine 5′-triphosphate-gated P2X4 receptor channel is a promising target in
neuroinflammatory disorders, but the ability to effectively target these receptors in models of …