Macronutrient metabolism plays an essential role in the overall health of an individual.
Depending on a number of variables, for example, diet, fitness level, or metabolic disease …

Background Our previous work demonstrated that a short-term high fat diet (HFD) increased
fasting serum endotoxin, altered postprandial excursions of serum endotoxin, and led to …

Objective The purpose of this investigation was to understand the metabolic adaptations to a
short‐term (5 days), isocaloric, high‐fat diet (HFD) in healthy, young males. Methods Two …

Background Diet-induced obesity is a rising health concern which can lead to the
development of glucose intolerance and muscle insulin resistance and, ultimately, type II …

Abstract Insulin resistance (IR), T2DM, and obesity together form a cluster of interrelated
metabolic challenges that may be linked by metabolic inflexibility. Metabolic inflexibility is …

Background The effects of diet-induced obesity on skeletal muscle function are largely
unknown, particularly as it relates to changes in oxidative metabolism and morphology …

Our objective was to determine the influence of a high-fat diet (HFD) on fasting and
postprandial skeletal muscle substrate metabolism in endurance-trained (ET) compared with …

The average human diet consists of a combination of carbohydrates (50%) and lipids (fats,
30%), delivered as meals in a discontinuous manner. Human physiology has evolved …

Fatty acid oversupply is a key mediator of skeletal muscle insulin resistance in obesity,
primarily via accumulation of fatty acid metabolites and activation of proinflammatory …

Diet‐induced obesity (DIO) is increasing in prevalence among youth; a time where robust
muscle growth occurs. We hypothesized that consumption of a high fat diet (HFD) in early …