Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …

Zinc is a trace element nutrient that is essential for life. This mineral serves as a cofactor for
enzymes that are involved in critical biochemical processes and it plays many structural …

Zinc (Zn), which is an essential trace element, is involved in numerous mammalian
physiological events; therefore, either a deficiency or excess of Zn impairs cellular …

Zinc is an essential trace element that plays important roles in the regulation of various
physiological responses in the body. Zinc deficiency is known to cause various health …

Zinc is an essential micronutrient, so it is important to elucidate the molecular mechanisms of
zinc homeostasis, including the functional properties of zinc transporters. Mammalian zinc …

▪ Abstract New insights into mammalian zinc metabolism have been acquired through the
identification and characterization of zinc transporters. These proteins all have …

All of the members of this family are thought to facilitate zinc efflux from the cytoplasm either
into various intracellular compartments (endosomes, secretory granules, synaptic vesicles …

The solute carriers families 30 (SLC30; ZnT), 39 (SLC39; ZIP), and 31 (SLC31; CTR) are
involved in the essential maintenance of cellular zinc (Zn 2+) and copper (Cu 2+) …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

In recent years, a number of mammalian zinc transporters have been identified, and
candidate genes are rapidly growing. These transporters are classified into two families: ZIP …