G-quadruplex structures are among the most interesting and best-characterized DNA folding
motifs.[1] DNA sequences that can form stable G-quadruplexes in vitro have been implicated …

A G-quadruplex is a four-stranded DNA structure featuring stacked guanine tetrads, G-
quartets. Formation of a G-quadruplex in telomere DNA can inhibit telomerase activity; …

A new family of G-quadruplex ligands termed “amido phthalocyanines”(APcs) was
synthesized by reacting variable amino acids with tetraamino zinc phthalocyanine. Variation …

Exploiting chemistry to develop compounds capable of selective recognition of biomolecules
or interfering with cellular processes is the essence of chemical biology.[1] One example of …

Guanine-rich nucleic acid sequences are known to form G-quadruplex-four-stranded DNA or
RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex …

Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions
regarding the possible presence and function of these intriguing structures in vivo remain …

We report bis-phenylethynyl amide derivatives as a potent G-quadruplex binding small
molecule scaffold. The amide derivatives were efficiently prepared in 3 steps by employing …

G-quadruplexes have gained prominence over the past two decades for their role in gene
regulation, control of anti-tumour activity and ageing. The physiological relevance and …

Guanine-rich sequences of DNA and RNA may fold in vitro and in vivo into G-quadruplexes,
four-stranded helical structures held together by a guanine core. G-quadruplexes have …

G-quadruplexes are higher-order DNA and RNA structures formed from G-rich sequences
that are built around tetrads of hydrogen-bonded guanine bases. There is considerable …