Angiogenesis is controlled by physical interactions between cells and extracellular matrix as
well as soluble angiogenic factors, such as VEGF. However, the mechanism by which …

Objective—Knockout studies have demonstrated crucial roles for the platelet-derived growth
factor-B and its cognate receptor, platelet-derived growth factor receptor-β (PDGFR-β), in …

Angiogenesis is a highly regulated process orchestrated by the VEGF system.
Heparin/heparan sulfate proteoglycans and neuropilin-1 (NRP-1) have been identified as co …

Angiogenesis in normal and pathological conditions is a multi-step process governed by
positive and negative endogenous regulators. Many growth factors are involved in different …

The formation of blood vessels (angiogenesis) is a highly orchestrated sequence of events
involving crucial receptor-ligand interactions. Angiogenesis is critical for physiological …

Platelet-derived growth factor receptor-beta (PDGFR-β) is expressed by endothelial cells
(ECs) of tumor-associated blood vessels and regulates primarily early hematopoiesis …

Vascular endothelial growth factor (VEGF) is a powerful regulator of neovascularization.
VEGF binding to its cognate receptor, VEGFR2, activates a number of signaling pathways …

Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation
through activation of three receptor tyrosine kinases, VEGFR-1,-2, and-3. The extracellular …

Background Angiogenesis plays an important role in tumor growth and metastasis. Methods
We review the function of the vascular endothelial growth factor (VEGF) in vessel formation …

Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration
and proliferation. Using bone marrow–derived human adult mesenchymal stem cells …