Preimplantation mouse embryos exposed to hyperglycemia, whether in vivo or in vitro,
experience delayed development from the 2-cell to blastocyst stage. By comparing …

The metabolic derangements of pregnancies complicated by diabetes mellitus, specifically
hyperglycaemia and hyper-ketonaemia, are known to be teratogenic during the period of …

Glucose metabolism was analysed in day-5 rat blastocysts incubated in the presence of [5-3
H]-,[6-14 C]-or [U-14 C] glucose. Glycolysis, quantified by 3 H 2 O recovery rate, was the …

The diabetic state, as well as elevated culture media glucose level (950 mg d-glucose/dL)
per se, significantly retards in vitro development of mouse pre-implantation embryos from a …

Glucose utilization was studied in preimplantation embryos from normal and diabetic mice.
With use of ultramicrofluorometric enzyme assays, intraembryonic free glucose in single …

Animal models of diabetes mellitus during pregnancy have repeatedly suggested that
maternal hyperglycemia was teratogenic during organogenesis, and thus may contribute to …

The effects of insulin, glucagon, β‐hydroxybutyrate, and acetoacetate on the in vitro
development of preimplantation mouse embryos were studied. In controls, 24% of …

Mouse preimplantation embryos consume pyruvate preferentially during the early
developmental stages, before glucose becomes the predominant energy substrate in the …

As congenital malformations may be caused by perturbations of glycolytic flux on early
embryogenesis [16], effects of hypoglycaemia were investigated by using rat embryo organ …

Congenital malformations and early fetal losses are still the main complications of diabetic
pregnancy. Whether the diabetic state affects the early embryo development during the …