Rationale The central serotonergic systems are a major target for drugs used to treat
neuropsychiatric disorders such as depression and schizophrenia in which disruption of …

Abstract Serotonin (5-HT) receptors are increasingly recognized as major targets for
cognitive enhancement in schizophrenia. Several lines of evidence suggest a …

Rationale. Converging evidence suggests that dopaminergic and serotonergic mechanisms
affect distinct aspects of cognitive performance. Experiments using the rodent five-choice …

Rationale: Whilst several studies have investigated the role of serotonergic receptor
subtypes in learning and memory, relatively few studies have examined their role in …

We investigated whether 5-HT 2A receptors contribute to the control of attentional
performance by glutamate NMDA receptor mechanisms in the medial prefrontal cortex …

Rationale Prefrontal cortex (PFC)-dependent executive function is disrupted in a range of
psychiatric disorders and can be modelled in non-human primates and rodents using …

Rationale Converging evidence implicates discrete areas of the rat prefrontal cortex in the
modulation of different aspects of attention and executive control. Furthermore, the …

A feature of multiple neuropsychiatric disorders is motor impulsivity. Recent studies have
implicated serotonin (5-HT) systems in medial prefrontal cortex (mPFC) in mediating …

It is widely acknowledged that the indoleamine neurotransmitter serotonin (5-HT) plays a
dual role in the regulation of anxiety, a role that in part depends upon neuroanatomical locus …

Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition,
attention and impulse control, implicating neuroregulatory abnormalities within this region in …