The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats
M Horiguchi, M Huang, HY Meltzer - Journal of Pharmacology and …, 2011 - ASPET
The role of 5-hydroxytryptamine (serotonin)(5-HT) 7 receptor antagonism in the actions of
atypical antipsychotic drugs (APDs), eg, amisulpride, clozapine, and lurasidone, if any, is …
atypical antipsychotic drugs (APDs), eg, amisulpride, clozapine, and lurasidone, if any, is …
The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats
Rationale Accumulating evidence indicates that schizophrenia and autism spectrum
disorder patients are marked by cognitive deficits in working memory and strategy switching …
disorder patients are marked by cognitive deficits in working memory and strategy switching …
Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats
TA Paine, HC Tomasiewicz, K Zhang… - Biological psychiatry, 2007 - Elsevier
BACKGROUND: Attentional deficits accompany many psychiatric disorders, underscoring
the need for rodent models of attention to screen novel therapeutic agents and characterize …
the need for rodent models of attention to screen novel therapeutic agents and characterize …
Pharmacological Blockade of Serotonin 5-HT7 Receptor Reverses Working Memory Deficits in Rats by Normalizing Cortical Glutamate Neurotransmission
The role of 5-HT7 receptor has been demonstrated in various animal models of mood
disorders; however its function in cognition remains largely speculative. This study evaluates …
disorders; however its function in cognition remains largely speculative. This study evaluates …
Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex
F Loiseau, A Dekeyne, MJ Millan - Psychopharmacology, 2008 - Springer
Rationale 5-HT 6 receptor antagonists improve cognitive processes in rodents. However,
their site (s) of action remains unexplored and their influence upon social memory has been …
their site (s) of action remains unexplored and their influence upon social memory has been …
Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist
A Fletcher, EA Forster, DJ Bill, G Brown, IA Cliffe… - Behavioural brain …, 1995 - Elsevier
Although considerable progress has been made in characterising the 5-HT1A receptor
using agonists, partial agonists or non-selective antagonists, further studies of 5-HT1A …
using agonists, partial agonists or non-selective antagonists, further studies of 5-HT1A …
Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT6 receptor antagonist: comparison among antipsychotics
JS Rodefer, TN Nguyen, JJ Karlsson… - …, 2008 - nature.com
Currently accepted treatments for schizophrenia can effectively control positive symptoms
but have limited impact on cognitive deficits in schizophrenia. The purpose of these …
but have limited impact on cognitive deficits in schizophrenia. The purpose of these …
M100907, A Selective 5-HT2A Receptor Antagonist and a Potential Antipsychotic Drug, Facilitates N-Methyl-D-Aspartate–Receptor Mediated Neurotransmission in the …
VL Arvanov, RY Wang - Neuropsychopharmacology, 1998 - nature.com
The technique of intracellular recording was used to examine the effect of M100907
(formerly MDL 100907), a highly selective 5-HT 2A receptor antagonist and a potential …
(formerly MDL 100907), a highly selective 5-HT 2A receptor antagonist and a potential …
5-HT2A receptors in the orbitofrontal cortex facilitate reversal learning and contribute to the beneficial cognitive effects of chronic citalopram treatment in rats
A Furr, MD Lapiz-Bluhm… - International Journal of …, 2012 - academic.oup.com
Chronic stress is a risk factor for depression, and chronic stress can induce cognitive
impairments associated with prefrontal cortical dysfunction, which are also major …
impairments associated with prefrontal cortical dysfunction, which are also major …
Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism
R Martın-Ruiz, MV Puig, P Celada… - Journal of …, 2001 - Soc Neuroscience
We examined the in vivo effects of the hallucinogen 4-iodo-2, 5-dimethoxyamphetamine
(DOI). DOI suppressed the firing rate of 7 of 12 dorsal raphe (DR) serotonergic (5-HT) …
(DOI). DOI suppressed the firing rate of 7 of 12 dorsal raphe (DR) serotonergic (5-HT) …