5-HT1A Receptor Agonists Enhance Pyramidal Cell Firing in Prefrontal Cortex Through a Preferential Action on GABA Interneurons
L Lladó-Pelfort, N Santana, V Ghisi, F Artigas… - Cerebral …, 2012 - academic.oup.com
HT1A receptors (5-HT1AR) are expressed by pyramidal and γ-aminobutyric acidergic
(GABAergic) neurons in medial prefrontal cortex (mPFC). Endogenous serotonin inhibits …
(GABAergic) neurons in medial prefrontal cortex (mPFC). Endogenous serotonin inhibits …
M100907 and clozapine, but not haloperidol or raclopride, prevent phencyclidine-induced blockade of NMDA responses in pyramidal neurons of the rat medial …
RY Wang, X Liang - Neuropsychopharmacology, 1998 - Elsevier
In the present study, we demonstrate that, in a concentration-dependent manner, M100907
(formerly MDL 100907, a highly selective 5-HT2A receptor antagonist and a purported …
(formerly MDL 100907, a highly selective 5-HT2A receptor antagonist and a purported …
The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity
A Bortolozzi, L Díaz‐Mataix, MC Scorza… - Journal of …, 2005 - Wiley Online Library
Atypical antipsychotics show preferential 5‐HT2A versus dopamine (DA) D2 receptor affinity.
At clinical doses, they fully occupy cortical 5‐HT2 receptors, which suggests a strong …
At clinical doses, they fully occupy cortical 5‐HT2 receptors, which suggests a strong …
Contrasting effects of systemic and intracerebral infusions of the 5-HT1A receptor agonist 8-OH-DPAT on spatial short-term working memory in rats
EC Warburton, AA Harrison, TW Robbins… - Behavioural brain …, 1997 - Elsevier
The present study compared the effects of systemic 8-OH-DPAT (0.05, 0.1 and 1.0 mg/kg)
with intra-raphe and intra-hippocampul infusions of 8-hydroxy-2-(di-n-propylamino) tetralin …
with intra-raphe and intra-hippocampul infusions of 8-hydroxy-2-(di-n-propylamino) tetralin …
Psychopharmacological approaches to modulating attention in the five-choice serial reaction time task: implications for schizophrenia
Y Chudasama, TW Robbins - Psychopharmacology, 2004 - Springer
Rationale In schizophrenia, attentional disturbance is a core feature which may not only
accompany the disorder, but may precede the onset of psychiatric symptoms. Objectives The …
accompany the disorder, but may precede the onset of psychiatric symptoms. Objectives The …
A pre‐ and postsynaptic modulatory action of 5‐HT and the 5‐HT2A, 2C receptor agonist DOB on NMDA‐evoked responses in the rat medial prefrontal cortex
VL Arvanov, X Liang, P Magro… - European Journal of …, 1999 - Wiley Online Library
Intracellular recordings were made from pyramidal neurons in layers V and VI of the rat
medial prefrontal cortex in slice preparations to investigate the effect of the serotonin 5 …
medial prefrontal cortex in slice preparations to investigate the effect of the serotonin 5 …
[HTML][HTML] Dopamine D1-like and D2-like receptors in the dorsal striatum control different aspects of attentional performance in the five-choice serial reaction time task …
L Agnoli, P Mainolfi, RW Invernizzi… - …, 2013 - nature.com
We investigated the interaction between the corticostriatal glutamatergic afferents and
dopamine D 1-like and D 2-like receptors in the dorsomedial striatum (dm-STR) in attention …
dopamine D 1-like and D 2-like receptors in the dorsomedial striatum (dm-STR) in attention …
Regulating Prefrontal Cortex Activation: An Emerging Role for the 5-HT2A Serotonin Receptor in the Modulation of Emotion-Based Actions?
The prefrontal cortex (PFC) is involved in mediating important higher-order cognitive
processes such as decision making, prompting thereby our actions. At the same time, PFC …
processes such as decision making, prompting thereby our actions. At the same time, PFC …
Effects of chronic treatment with escitalopram or citalopram on extracellular 5‐HT in the prefrontal cortex of rats: role of 5‐HT1A receptors
I Ceglia, S Acconcia, C Fracasso… - British journal of …, 2004 - Wiley Online Library
Microdialysis was used to study the acute and chronic effects of escitalopram (S‐citalopram;
ESCIT) and chronic citalopram (CIT), together with the 5‐HT1A receptor antagonist …
ESCIT) and chronic citalopram (CIT), together with the 5‐HT1A receptor antagonist …
Activity of Serotonin 5-HT1A Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties
M Jastrzębska-Więsek, A Partyka… - ACS chemical …, 2017 - ACS Publications
Although serotonin 5-HT1A receptors constitute attractive therapeutic targets, there is a lack
of potential clinical candidates that have a high degree of selectivity and full agonist efficacy …
of potential clinical candidates that have a high degree of selectivity and full agonist efficacy …