Attentional deficits are core symptoms of schizophrenia, contributing strongly to disability.
Prefrontal dysfunction has emerged as a candidate mechanism, with clinical evidence for …

The effects of 5-HT2 receptor ligands on the performance of rats were investigated using a 5-
choice serial reaction time (5-CSRT) task. Systemic administration of DOI (0.03 to 0.3 mg/kg …

Previous research has suggested that serotonin 5-HT2A receptors modulate the functioning
of the mesocortical dopamine (DA) pathway. However, the specific role of 5-HT2A receptors …

The activation of 5-HT2A receptors in medial prefrontal cortex (mPFC) by the hallucinogen
DOI increases the firing activity of dorsal raphe (DR) 5-HT neurons and prefrontal 5-HT …

BACKGROUND: At low and clinically relevant doses, psychostimulants enhance cognitive
and behavioral function dependent on the prefrontal cortex (PFC) and extended …

A disturbance in 5-HT signalling can lead to maladaptive and disruptive behavioural
changes seen in neuropsychiatric disorders, potentially by 5-HT's role in cognitive control …

The prefrontal cortex (PFC) plays a key role in many high-level cognitive processes. It is
densely innervated by serotonergic neurons originating from the dorsal and median raphe …

5‐Hydroxytryptamine (5‐HT) plays a role in the regulation of 3, 4‐
dihydroxyphenylethylamine (dopamine) neurons in the brain, but the precise mechanism of …

Both medial prefrontal cortex (mPFC) and serotonin play key roles in anxiety; however,
specific mechanisms through which serotonin might act on the mPFC to modulate anxiety …

BACKGROUND AND PURPOSE 5‐HT6 receptors are abundant in the hippocampus,
nucleus accumbens and striatum, supporting their role in learning and memory. Selective 5 …