Maladaptive levels of impulsivity are found in several neuropsychiatric disorders, such as
ADHD, addiction, aggression and schizophrenia. Intolerance to delay-of-gratification, or …

Rationale. Cognitive impairment is a common feature of depressive illness. While
accumulating evidence suggests that brain serotonin (5-HT) pathways play an important role …

Rationale. Rats reared in social isolation exhibit hyperactivity and specific attentional
disturbances in later adult life. These behavioural abnormalities may be relevant to …

The in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT6R
antagonist Lu AE58054 ([2-(6-fluoro-1 H-indol-3-yl)-ethyl]-[3-(2, 2, 3, 3-tetrafluoropropoxy) …

The serotonin 1A (5-HT1A) receptor is one of the best described receptor subtypes of the
serotonergic system. Due to the complex distribution pattern, the pre-and postsynaptic …

Selective serotonin reuptake inhibitors like paroxetine (Prx) often requires 4–6 weeks to
achieve clinical benefits in depressed patients. Pindolol shortens this delay and it has been …

Background and purpose: Activation of post‐synaptic 5‐HT1A receptors may provide
enhanced therapy against depression. We describe the signal transduction profile of …

Rationale: 5-HT 6 receptors are predominantly located in the brain and may be involved in
cognitive processes. The aim of this study was to assess the effects of two potent and …

Depressed patients suffer from cognitive dysfunction, including memory deficits. Acute
serotonin (5-HT) depletion impairs memory and mood in vulnerable patients. The …

The serotonergic pathways originating in the dorsal and median raphe nuclei (DR and MnR,
respectively) are critically involved in cortical function. Serotonin (5-HT), acting on …