Methylenetetrahydrofolate reductase (MTHFR) regulates the intracellular folates pool for
DNA synthesis and methylation. Sequence variations in MTHFR (nucleotides 677 (C→ T) …

Background Two functional single nucleotide polymorphisms (SNPs) in the 5, 10-
methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to …

Published data on the association between MTHFR C677T polymorphism and breast cancer
risk are inconclusive. To derive a more precise estimation of the relationship, a meta …

The methylenetetrahydrofolate reductase (MTHFR) gene is a polymorphic gene involved in
folate metabolism, DNA biosynthesis, methylation and genomic integrity in actively dividing …

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5. 1.20), that reduces 5,
10‐methylenetetrahydrofolate to 5‐methyltetrahydrofolate, a carbon donor for the …

Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and plays a
role in DNA biosynthesis, methylation, and repair in actively dividing cells. A common 677C> …

Background: Breast cancer is the most common cancer among women. 1 in every 8 women
in the United States have a lifetime risk of getting breast cancer. MTHFR is a key enzyme …

We performed a case-control study to investigate the association between single nucleotide
polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This …

Background A growing body of evidence suggests that variations in the levels of folate may
contribute to the development of cancer. A functional polymorphic variant (C→ T substitution …

Objective The 677 C> T and 1298 A> C polymorphisms of methylenetetrahydrofolate
reductase (MTHFR) gene have been widely reported and considered to have a significant …