We describe seven Turkish children with DOCK8 deficiency who have not been previously
reported. Three patients presented with typical features of recurrent or severe cutaneous …

DOCK8 deficiency affects various cell subsets belonging to both the innate and adaptive
immune systems. Clinical diagnosis is challenging, as many cases present with severe …

DOCK8 deficiency is a primary immunodeficiency characterized by recurrent sinopulmonary
infections, dermatitis with cutaneous infections, elevated serum IgE levels, eosinophilia, and …

Mutations in DOCK8 result in autosomal recessive Hyper-IgE syndrome with combined
immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and …

DOCK 8 immunodeficiency syndrome (DIDS) is a progressive combined immunodeficiency
that can be distinguished from other combined immunodeficiencies or …

Dedicator of cytokinesis 8 (DOCK8) deficiency is an innate error of adaptive immunity
characterized by recurrent infections with viruses, bacteria, and fungi, typically high serum …

Background Biallelic variations in the dedicator of cytokinesis 8 (DOCK8) gene cause a
combined immunodeficiency with eczema, recurrent bacterial and viral infections, and …

Dedicator of cytokinesis 8 protein (DOCK8) deficiency is a combined immunodeficiency
disorder characterized by an expanding clinical picture with typical features of recurrent …

To the Editor, Combined immunodeficiencies (CIDs) consist of a group of disorders
characterized by defects in the quantity and/or function of T cells along with defects in …

The discovery that loss‐of‐function mutations in the gene DOCK8 are responsible for most
forms of autosomal recessive hyper‐IgE syndrome and some forms of combined …