Esophageal cancer is one of the most lethal human tumors, characterized by relative
chemoresistance and poor prognosis. Researchers have been seeking for multimodality to …

Purpose: Lung cancer, the leading cause of cancer mortality worldwide, is often diagnosed
at late stages and responds poorly to conventional therapies, including chemotherapy and …

PURPOSE/OBJECTIVE.: To investigate whether exogenous PUMA expression suppresses
the growth of drug-resistant choriocarcinoma cells and sensitizes them to chemotherapeutic …

Replacement of the p53 tumor suppressor gene is a rational approach to the management
of malignant gliomas because p53 is frequently mutated or inactivated in these cancers …

Head and neck squamous cell carcinoma (HNSCC) ranks the eighth most common cancer
worldwide. The patients often present with advanced disease, which responds poorly to …

PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2
family member and a critical mediator of p53-dependent and-independent apoptosis …

Defective apoptosis contributes to tumorigenesis, although the critical molecular targets
remain to be fully characterized. PUMA, a BH3-only protein essential for p53-dependent …

PUMA (p53 upregulated modulator of apoptosis), a member of the B‑cell lymphoma 2 (Bcl-2)
protein family, is a pro‑apoptotic protein. PUMA expression is modulated by the tumor …

Malignant melanoma is an aggressive and chemoresistant form of skin cancer characterized
by rapid metastasis and poor patient prognosis. The development of innovative therapies …

The tumor suppressor protein p53 plays a key role in regulation of negative cellular growth
in response to EGCG. To further explore the role of p53 signaling and elucidate the …