Various pathogenic factors can lead to oogenesis failure and seriously affect both female
reproductive health and fertility. Genetic factors play an important role in folliculogenesis and …

Successful human reproduction requires gamete maturation, fertilization, and early
embryonic development. Human oocyte maturation includes nuclear and cytoplasmic …

About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

To show that disruption of meiotic competence results in cell cycle arrest, and the production
of immature oocytes that are not capable of fertilization. Through an extensive review of …

Premature ovarian insufficiency (POI) is defined as the cessation of ovarian function under
the age of 40 years and is characterized by amenorrhea, hypoestrogenism, and elevated …

OBJECTIVE: To evaluate the relationship between mitochondrial gene expression of
oocytes/embryos and their fertilizability in unfertilized oocytes, arrested embryos, and …

Reproductive diseases are a long‐standing problem and have become more common in the
world. Currently, 15% of the world's population suffers from infertility, and half of them are …

Mitochondrial DNA (mtDNA) point mutations are known to accumulate in an age-dependent
fashion in somatic tissues. This study investigated whether a point mutation (T414G) in the …

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …