Oogenesis involves complex differentiation program leading to the production of functional
oocytes. Oogonia originating from primordial germ cells proliferate by mitosis and form …

Mitochondrial DNA (mtDNA) point mutations are known to accumulate in an age-dependent
fashion in somatic tissues. This study investigated whether a point mutation (T414G) in the …

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …

Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …

Molecular geneticists and ovarian physiologists today face the challenge of defining and
reconciling two major biological imperatives that each center on oogenesis, folliculogenesis …

The decline of oocyte quality has profound impacts on fertilization, implantation, embryonic
development, and the genetic quality of future generations. One factor that is often ignored …

BACKGROUND: Mitochondrial biogenesis and bioenergetics play an important role in
oocyte maturation and embryo development. We have investigated the relationship between …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Total fertilization failures (TFF) are rare events of IVF by intracytoplasmic sperm injection
(ICSI). When male factor is excluded, the lack of identifiable aetiological criteria raises the …