Primary ovarian insufficiency (POI) is a critical fertility defect characterized by an anticipated
and silent impairment of the follicular reserve, but its pathogenesis is largely unexplained …

Background Oocyte maturation arrest and early embryonic arrest are important reproductive
phenotypes resulting in female infertility and cause the recurrent failure of assisted …

Primary ovarian insufficiency (POI), also known as premature ovarian failure (POF), is
defined as more than six months of cessation of menses before the age of 40 years, with two …

BACKGROUND Primary ovarian insufficiency (POI) is characterized by marked
heterogeneity, but with a significant genetic contribution. Identifying exact causative genes …

Purpose To identify candidate variants in genes possibly associated with premature ovarian
insufficiency (POI). Methods Fourteen women, from 7 families, affected by idiopathic POI …

Oocyte quality is a well-established determinant of embryonic fate. However, the molecular
participants and biological markers that affect and may predict adequate embryonic …

Mitochondria play a fundamental role during development of the female germline. They are
fragmented, round, and small. Despite these characteristics suggesting that they are …

Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …

Oocyte mitochondria are increased in number, smaller, and rounder in appearance than
mitochondria in somatic cells. Moreover, mitochondrial numbers and activity are narrowly …

Mitochondrial DNA (mtDNA) of oocyte is critical for its function, embryo quality and
development. Analysis of complete mtDNA of 49 oocytes and 18 blastocysts from 67 females …