STUDY QUESTION Does ovarian ageing increase the number of heteroplasmic
mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER Our results …

Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles
associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep …

Mitotic errors are common in human preimplantation embryos. The occurrence of mitotic
errors is highest during the first three cleavages after fertilization and as a result about three …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

Embryo development requires orchestrated events, finely regulated at the molecular and
cellular level by mechanisms which are progressively emerging from animal studies. With …

This review presents the genetic disorders associated with premature ovarian failure (POF),
obtained by Medline, the Cochrane Library and hand searches of pertinent references of …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

STUDY HYPOTHESIS Maternal ageing and ovarian stimulation result in the accumulation of
mitochondrial DNA (mtDNA) deletions and heteroplasmy in individual oocytes from a novel …

Premature ovarian failure (POF) is identified as a heterogeneous disorder leading to
amenorrhea and ovarian failure before the age of 40 years. The first known symptom of the …

Early embryonic arrest and fragmentation (EEAF) is a common phenomenon leading to
female infertility, but the genetic determinants remain largely unknown. The Moloney …