Purpose The fertility of women decreases with age because of factors such as an increased
incidence of aneuploidies and—possibly—decreased mitochondrial activity in oocytes …

Objective To understand role of mitochondrial (mt) mutations in genes regulating oxidative
phosphorylation (OXPHOS) in pathogenesis of male infertility. Infertility affects approximately …

Obesity is associated with ovulatory disorders, decreased rates of conception, infertility,
early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF …

Using a semi-quantitative review of published electron micrographs, we have explored the
passage of mitochondria from one generation to the next through the cytoplasm of the …

Mitochondria are commonly recognized as the powerhouses of the cell, primarily
responsible for energy production through oxidative phosphorylation. Alongside this vital …

Infertility is described as unexplained when pregnancy does not occur despite ovulation,
patent Fallopian tubes, and normal semen parameters. Oocyte developmental competence …

Ovarian deficiency, including premature ovarian insufficiency (POI) and diminished ovarian
reserve (DOR), represents one of the main causes of female infertility. POI is a genetically …

Mitochondrial dysfunction can cause female infertility. An important unresolved issue is the
extent to which incompatibility between mitochondrial and nuclear genomes contributes to …

Many women suffer from either failed fertilisation or their embryos arrest early during
development. Autologous mitochondrial supplementation has been proposed as an assisted …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …