One of the most critical issues to be solved in reproductive medicine is the treatment of
patients with multiple failures of assisted reproductive treatment caused by low-quality …

Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How
these flaws relate to phenotypes of oocyte developmental compromise associated with …

Mitochondrial dysfunction may be acquired or inherited by oocytes without detectable
morphological abnormalities. This pathology may account for some examples of …

STUDY QUESTION What are the molecular differences between mitochondrial DNA
(mtDNA)-deficient and mtDNA-normal oocytes and how does mitochondrial …

Premature ovarian failure (POF) is unexplained amenorrhoea (> 6months), increased FSH
(> 20IU/l) and LH occurring before 40years. Several genes are reported as having …

Purpose Premature ovarian insufficiency (POI) is a heterogeneous disorder characterized by
the cessation of menstrual cycles before the age of 40 years due to the depletion or …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

In mammals, the ovarian reserve of primordial follicles is constituted early in fetus, then it
becomes progressively exhausted by both follicular development and oocyte apoptosis. At …

Oocyte maturation abnormalities (OMAS) are a poorly understood area of reproductive
medicine. Much remains to be understood about how OMAS occur. However, current …

Mitochondrial production of cellular energy is essential to oocyte function, zygote
development and successful continuation of pregnancy. This review focuses on several key …