Oocyte mitochondrial dysfunction has been proposed as a cause of high levels of
developmental retardation and arrest that occur in human preimplantation embryos …

Purpose The change of mitochondrial distribution in human oocytes during meiotic
maturation was assessed using 223 human oocytes donated from patients undergoing …

The biggest cell in the human body, the oocyte, encloses almost the complete machinery to
start life. Despite all the research performed to date, defining oocyte quality is still a major …

Many different genetic abnormalities have been reported in human oocytes. The most
common egg abnormality results from an error in chromatid segregation during the first …

STUDY QUESTION Does maternal ageing and ovarian stimulation alter mitochondrial DNA
(mtDNA) copy number and gene expression of oocytes and cumulus cells from a novel …

Objective To investigate possible causes of in vitro fertilization (IVF) failure. Design A
retrospective cytogenetic study of human oocytes divided into four groups or, alternatively …

The mammalian ovary is an organ that controls female germ cell development, storing them
and releasing mature oocytes for transporting to the oviduct. During the fetal stage, female …

Genetic defects of the mitochondrial genome can be especially devastating to patients;
moreover, attention on human mitochondrial disorders has grown remarkably in recent …

There is a worldwide trend for women to have their first pregnancy later in life. However, as
oocyte quality declines with maternal aging, this trend leads to an increase in subfertility …

Oocytes play a pivotal role in the cycle of human life. As we discuss here, after emerging
from germline stem cells in the fetus, they grow in a follicular niche in which development is …