Evaluating the benefits of an antihypertensive agent using trials based on event and organ damage: the Systolic Hypertension in the Elderly Long-term Lacidipine …

A Zanchetti - Journal of Hypertension, 1995 - journals.lww.com
Evaluating the benefits of an antihypertensive agent using t... : Journal of Hypertension
Evaluating the benefits of an antihypertensive agent using trials based on event and organ …

Lacidipine: a review of its use in the management of hypertension

PL McCormack, AJ Wagstaff - Drugs, 2003 - Springer
Summary Abstract Lacidipine (Caldine®, Lacimen®, Lacipil®, Midotens®, Motens®) is a
once-daily, orally-administered, lipophilic dihydropyridine calcium antagonist with an …

Safety aspects of treatment with lacidipine—a slow-onset, long-acting calcium antagonist

LH Lindholm, P Tcherdakoff, A Zanchetti - Blood pressure, 1996 - Taylor & Francis
Objective: The aim was to review the clinical safety profile of lacidipine with the help of the
rather comprehensive datafile of the manufacturer-a novel approach which may be of some …

Systolic Hypertension in the Elderly: Long-Term Lacidipine Treatment: Objective, Protocol, and Organization

E Malacco, AE Gnemmi, A Romagnoli… - Journal of …, 1994 - journals.lww.com
Isolated systolic hypertension (ISH) is a definite risk factor for cardiovascular complications
(ie, cardiac failure, coronary artery disease, and stroke) independent of diastolic elevation …

The potential advantages of a modern antihypertensive therapy in the elderly

F Zannad - Journal of Cardiovascular Pharmacology, 2000 - journals.lww.com
More than 50% of hypertensive patients are aged above 65 years. Physiopathology of
essential hypertension is different in the elderly as compared with the young adult …

French large-scale study evaluating the tolerability and efficacy of lacidipine

P Tcherdakoff - Journal of Cardiovascular Pharmacology, 1995 - journals.lww.com
In a large, open, multicenter study, 2,206 outpatients with mild-to-moderate essential
hypertension were recruited by 755 cardiologists throughout France. Patients received …

Safety of the calcium antagonist lacidipine evaluated from a phase III–IV trial database

LH Lindholm, P Tcherdakoff… - Journal of Hypertension, 1996 - journals.lww.com
Objective We reviewed the clinical safety profile of lacidipine with the help of the rather
comprehensive data file of the manufacturer. Although a number of prospective, randomly …

Impact of calcium antagonists on the cardiovascular system: experience with lacidipine

E Kuschnir - Drugs, 1999 - Springer
The evaluation of haemodynamic patterns in hypertensive patients by radionuclide
techniques and a tomographic gamma camera has revealed differences between older and …

Efficacy and safety of lacidipine, a new long-lasting calcium antagonist, in elderly hypertensive patients

P Rizzini, C Castello, S Salvi… - Journal of cardiovascular …, 1991 - journals.lww.com
Elderly patients are becoming a greater proportion of the hypertensive population. In
addition, they may respond differently to drugs, both pharmacodynam-ically and …

What, if anything, is controversial about calcium antagonists?

FH Messerli - American journal of hypertension, 1996 - academic.oup.com
Recent publications purporting to show that calcium antagonists, when used for the
treatment of hypertension or in the post myocardial infarction patient, would paradoxically …