Vascular ADAM17 as a novel therapeutic target in mediating cardiovascular hypertrophy and perivascular fibrosis induced by angiotensin II
T Takayanagi, SJ Forrester, T Kawai, T Obama… - …, 2016 - Am Heart Assoc
Angiotensin II (AngII) has been strongly implicated in hypertension and its complications.
Evidence suggests the mechanisms by which AngII elevates blood pressure and enhances …
Evidence suggests the mechanisms by which AngII elevates blood pressure and enhances …
Understanding angiotensin II type 1 receptor signaling in vascular pathophysiology
2 Hypertension May 2018 acknowledged in VSMCs, whether it has any significance in
vascular pathophysiology linked to angiotensin II had not been studied. Recently, our group …
vascular pathophysiology linked to angiotensin II had not been studied. Recently, our group …
Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile–Induced Abdominal Aortic Aneurysm
T Kawai, T Takayanagi, SJ Forrester, KJ Preston… - …, 2017 - Am Heart Assoc
Angiotensin II (AngII)–activated epidermal growth factor receptor has been implicated in
abdominal aortic aneurysm (AAA) development. In vascular smooth muscle cells (VSMCs) …
abdominal aortic aneurysm (AAA) development. In vascular smooth muscle cells (VSMCs) …
Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage
M Shen, J Morton, ST Davidge, Z Kassiri - Journal of molecular and cellular …, 2017 - Elsevier
Hypertension is associated with hypertrophy and hyperplasia of smooth muscle cells
(SMCs). Disintegrin and metalloproteinase 17 (ADAM17) is a membrane-bound enzyme …
(SMCs). Disintegrin and metalloproteinase 17 (ADAM17) is a membrane-bound enzyme …
Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α
T Obama, T Takayanagi, T Kobayashi… - American journal of …, 2015 - academic.oup.com
BACKGROUND A disintegrin and metalloprotease 17 (ADAM17) is a membrane-spanning
metalloprotease overexpressed in various cardiovascular diseases such as hypertension …
metalloprotease overexpressed in various cardiovascular diseases such as hypertension …
Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes
G Weskamp, K Mendelson, S Swendeman… - Circulation …, 2010 - Am Heart Assoc
Rationale: Pathological neovascularization is a critical component of diseases such as
proliferative retinopathies, cancer and rheumatoid arthritis, yet much remains to be learned …
proliferative retinopathies, cancer and rheumatoid arthritis, yet much remains to be learned …
ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis
P Göőz, M Göőz, A Baldys, S Hoffman - Biochemical and biophysical …, 2009 - Elsevier
Modulation of angiogenesis is a promising approach for treating a wide variety of human
diseases including ischemic heart disease and cancer. In this study, we show that ADAM-17 …
diseases including ischemic heart disease and cancer. In this study, we show that ADAM-17 …
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy
X Wang, FL Chow, T Oka, L Hao… - Circulation, 2009 - Am Heart Assoc
Background—Excessive stimulation of Gq protein–coupled receptors by cognate
vasoconstrictor agonists induces a variety of cardiovascular processes, including …
vasoconstrictor agonists induces a variety of cardiovascular processes, including …
ADAM12: a genetic modifier of preclinical peripheral arterial disease
AO Dokun, L Chen, M Okutsu… - American Journal …, 2015 - journals.physiology.org
In prior studies from multiple groups, outcomes following experimental peripheral arterial
disease (PAD) differed considerably across inbred mouse strains. Similarly, in humans with …
disease (PAD) differed considerably across inbred mouse strains. Similarly, in humans with …
ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II
H Ohtsu, PJ Dempsey, GD Frank… - … , and vascular biology, 2006 - Am Heart Assoc
Background—Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells
(VSMCs) via epidermal growth factor (EGF) receptor (EGFR) transactivation mediated …
(VSMCs) via epidermal growth factor (EGF) receptor (EGFR) transactivation mediated …