Preterm birth (PTB) is a syndrome with many origins. Among them, infection or inflammation
are major risk factors for PTB; however, local defense mechanisms to mount anti …

Infection-driven inflammation in pregnancy is a major cause of spontaneous preterm birth
(PTB). Both systemic infection and bacterial ascension through the vagina/cervix to the …

It is known that excessive inflammation at fetal-maternal interface is a key contributor in a
compromised pregnancy. Female genital tract is constantly in contact with microorganisms …

Unlike organ transplants where an immunosuppressive environment is required, a
successful pregnancy involves an extremely robust, dynamic, and responsive maternal …

Preterm birth is a leading cause of neonatal morbidity and mortality. Despite a growing body
of evidence correlating inflammation with preterm birth, the signal transduction pathways …

Background Preterm birth remains a leading obstetrical complication because of the
incomplete understanding of its multifaceted etiology. It is known that immune alterations …

Introduction During the first trimester of human pregnancy, fetally-derived extravillous
trophoblast (EVT) invade into the uterine decidua and remodel the uterine spiral arteries to …

Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide. A
transition from an anti-inflammatory state to a pro-inflammatory state in the mother and at the …

With half a million babies born preterm each year in the USA and about 15 million
worldwide, preterm birth (PTB) remains a global health issue. Preterm birth is a primary …

Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …