Purpose.: Primary open-angle glaucoma (POAG) is the most common form of glaucoma and
is accompanied by elevated intraocular pressure (IOP) resulting from increased aqueous …

Increased synthesis and deposition of extracellular matrix (ECM) proteins in the trabecular
meshwork (TM) is associated with TM dysfunction and intraocular pressure (IOP) elevation …

The trabecular meshwork (TM) is known to be subjected to different types of stress such as
mechanical, oxidative, and phagocytic stress. Although short-term exposure to these …

Purpose: This study aimed to investigate the differential responses of trabecular meshwork
stem cells (TMSCs) and trabecular meshwork (TM) cells to endoplasmic reticulum (ER) …

Purpose To investigate the mechanisms by which chronic oxidative stress may lead to a
sustained stress response similar to that previously observed in the trabecular meshwork …

Purpose: To investigate the effects of endoplasmic reticulum (ER) stress on the tight
junctions of the retinal pigment epithelial (RPE) cells in vitro. Materials and Methods: ER …

Axon injury is an early event in neurodegenerative diseases that often leads to retrograde
neuronal cell death and progressive permanent loss of vital neuronal functions. The …

Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, and lowering IOP
remains the only effective treatment for glaucoma. The trabecular meshwork (TM) in the …

Ocular hypertension arising from increased resistance to aqueous humor (AH) outflow
through the trabecular meshwork is a primary risk factor for open-angle glaucoma, a leading …

Elevated intraocular pressure (IOP) is thought to create distortion or stretching of the
juxtacanalicular and Schlemm's canal cells and their extracellular matrix (ECM) leading to a …