Rationale: Chronic obstructive pulmonary disease (COPD) is thought to result in rapid and
progressive loss of lung function usually expressed as mean values for whole cohorts …

Rationale: Although the rate of annual decline in FEV1 is one of the most important outcome
measures in chronic obstructive pulmonary disease (COPD), little is known about …

Rationale: Chronic obstructive pulmonary disease (COPD) can develop not only through a
lung function trajectory dominated by an accelerated decline of FEV1 from normal maximally …

Background Chronic obstructive pulmonary disease (COPD) is thought to result from an
accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is …

Rationale: Chronic obstructive pulmonary disease (COPD) seems to be a heterogeneous
disease with a variable course. Objectives: We wished to characterize the heterogeneity and …

COPD is complex and there are multiple determinants of poor health, so most studies of
Chronic Obstructive Pulmonary Disease (COPD) now include health status, or health related …

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation that is not fully reversible (1). Like many other major chronic diseases the burden …

Chronic obstructive pulmonary disease (COPD), although frequent in older individuals, can
also occur at younger age; this latter population has not been well described. We reviewed …

Background Chronic obstructive pulmonary disease (COPD) is characterized by an
incompletely reversible limitation in airflow. A physiological variable—the forced expiratory …

Rationale: Little is known about the long-term outcomes of individuals with mild/moderate
chronic obstructive pulmonary disease (COPD) according to spirometric criteria. Objectives …