Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the
homeostasis of a healthy network of functioning mitochondria and prevents excessive …

Mitochondria are critical for supplying energy to the cell, but during catabolism this organelle
also produces reactive oxygen species that can cause oxidative damage. Accordingly …

Parkinson's disease genes PINK1 and parkin encode kinase and ubiquitin ligase,
respectively. The gene products PINK1 and Parkin are implicated in mitochondrial …

Damage to mitochondria can lead to the depolarization of the inner mitochondrial
membrane, thereby sensitizing impaired mitochondria for selective elimination by …

Mitophagy, a mitochondria-specific form of autophagy, removes dysfunctional mitochondria
and is hence an essential process contributing to mitochondrial quality control. PTEN …

Mutations in the genes encoding the mitochondrial kinase PINK 1 and the E3 ubiquitin
ligase Parkin cause autosomal recessive Parkinson's disease (PD). Pioneering work in …

The PTEN-induced putative kinase 1 (PINK1) is a mitochondrially targeted serine–threonine
kinase, which is linked to autosomal recessive familial parkinsonism. Current literature …

Autophagy is the process by which cells can selectively or non-selectively remove damaged
proteins and organelles. As the cell's main means of sequestering damaged mitochondria …

Mutations in the E3 ubiquitin ligase Parkin and the mitochondrial PTEN-induced putative
kinase 1 (PINK1) have been identified to cause autosomal recessive forms of familial …

A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis.
Normally, damaged mitochondria are cleared via a major pathway that involves the E3 …