Nuclear reprogramming technology was first established more than 50 years ago. It can
rejuvenate somatic cells by erasing the epigenetic memories and reconstructing a new …

The identification of transcription factors to induce pluripotency directly in somatic cells has
given researchers a unique platform on which to dissect the mechanisms underlying …

Recent advances in nuclear reprogramming technology allow the transformation of
terminally differentiated, adult cells into induced pluripotent stem cells whose phenotype is …

The concept of reversing the characteristics of differentiated tissues to pluripotency through
reprogramming was introduced over 50 years ago in the first somatic cell nuclear transfer …

Nuclear reprogramming generates induced pluripotent stem (iPS) cells endowed with the
unlimited potential to reconstruct genetically identical tissues. This biomedical tool offers …

Since the seminal discovery by Yamanaka et al. demonstrating that four transcription factors
were capable of inducing nuclear reprogramming to a pluripotent state, a plethora of …

Cell reprogramming, in which a differentiated cell is made to switch its fate, is an emerging
field with revolutionary prospects in biotechnology and medicine. The recent discovery of …

The somatic epigenome can be reprogrammed to a pluripotent state by a combination of
transcription factors. Altering cell fate involves transcription factors cooperation, epigenetic …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

The ground-breaking work of Yamanaka and Thomson showed that forced expression of
just four transcription factors can reprogram mouse and human somatic cells to pluripotency …